An Overview of Medical Genetics Lab of Dr Zamani

Medical Genetics Laboratory of Dr Zamani as a well-known private center provides a wide variety of medical genetics tests and services. The director, Dr Mehdi Zamani, has PhD in Medical genetics and post-doctorate in genetic diseases and risk factor analysis both from Leuven University, Belgium. Dr. Zamani is a faculty member of Tehran University of Medical Sciences. He is the founder, as well as, the current director of Medical Genetics Division of Children’s Clinical Center Hospital and Medical Genetics Laboratory of Dr. Zamani

Dr. Zamani is a member of the following societies:

-New york Academy of Science

-European Association of Diabetes Study (EADS)

-The exclusive representative of EU’s Thematic network for CF disease in Iran.

Having been graduated from Leuven university in 1997, Dr Zamani has since been actively involved in the molecular diagnosis and genetic counseling of the genetic diseases both at Medical Genetics Division of Children’s Clinical Center hospital and his private lab.

A list of the international published papers by Dr Zamani is shown:

Author of publications in international Journals

1. Zamani Ghabanbasani M, Buyse I, Legius E, Decorte R, Marynen P, Bouillon R and Cassiman JJ (1994): Possible association of CD3 and CD4 Polymorphisms with IDDM. Clin. Exp. Immunology 97:517-521

2. Zamani Ghabanbasani M, Spaepen M, Buyse I, Marynen P, Bex M, Bouillon R and Cassiman JJ (1994): Improved risk assessment for IDDM by analysis of amino acids in HLA- DQ and DRB1 loci. Eur J Human Genetics 2:177-184

3. Zamani Ghabanbasani M, De Hert M, Spaepen M, Hermans M, Marynen P, Cassiman JJ and Peuskens J (1994): Study of the possible association of HLA class II, CD4 and CD3 polymorphisms with schizophrenia. Am J Medical Genetics. 54:372-377

4. Buyse I, Sandkuyl LA, Zamani Ghabanbasani M, Gu XX, Bouillon R, BeX M, Dooms L, Emonds MP, Duhamel M, Marynen P and Cassiman JJ (1994): Association of particular HLA class II alleles, haplotypes, and genotypes with susceptibility to insulin dependent diabetes mellitus in the Belgian population. Diabetologia 37:808-817

5. Decorte R, Buyse I, Zamani M, Gu XX, Spaepen M, Marynen P, De Canck l, Emonds M and Cassiman JJ (1994): Distribution of HLA Class II genes in a Caucasian population as determined by PCR and reversed-dot-blot typing. Adv. Forensic Haemogenet. 5:490-492

6. Vandevyver C, Buyse I, Philippaerts L, Zamani Ghabanbasani M, Medaer R, Carton H, Cassiman JJ and Raus J (1994): HLA and T-cell receptor polymorphisms in Belgian multiple sclerosis patients. J of Neuroimmonology 52:25-32

7. Zamani Ghabanbasani M , Spaepen M, Buyse I, Legius E, Decorte R, Bex M, Marynen P, Bouillon R and Cassiman JJ (1995): Increased and decreased relative risk for Non- insulin-dependent diabetes mellitus conferred by HLA class II and by CD4 alleles. Clinical Genetics 47:225-230.

8. Zamani Ghabanbasani M, Gu XX, Spaepen M, Vandevyver C, Raus J, Marynen P, Carton H and Cassiman JJ (1995): Importance of HLA-DRB1 and DQA1 genes and of the amino acid polymorphisms in the functional domain of DRB1 chain in Multiple Sclerosis. J of Neuroimmonology 59:77-82.

9. Zamani M, Pociot F, Raeymaekers P, Nerup J and Cassiman JJ (1996): Linkage of type I diabetes to 15q26 (IDDM3) in Danish population. Human Genet 98:491-496

10. Zamani M, Pociot F, Spaepen M, Raeymaekers P, Nerup J and Cassiman JJ (1996): Linkage and association of the HLA gene complex with IDDM in Danish families: Strong linkage between DRb1^Lys71+ and IDDM. J Medical Genetics 33:899-905

11. Zamani M and Cassiman JJ. (1998) : Reevaluation of the importance of polymorphic HLA class II alleles and amino acids in the susceptibility of individuals to type I Diabetes in different populations. Am J Medical Genetics 76:183-194

12. Kiristiansen OP, Zamani M, Johannesen J, Mandrup-Poulsen T, Cassiman JJ, Nerup J, Pociot F, DIEGG and DSGD(1998): Linkage between a CD4 gene polymorphism and IDDM in Danish IDDM patients. Diabetes 47:281-283

13. Pandey J, Zamani M and Cassiman JJ. (1999) : Epistatic effects of genes encoding tumor necrosis factor a, immunoglobulin allotypes, and HLA antigens on susceptibility to non-insulin dependent (type 2) diabetes. Immunogenetics 49:860-864

14. Zamani M , Spaepen M, Bex M, , Bouillon R and Cassiman JJ (2000): Primary role of the HLA class II DRB1*0301 allele in Graves' Disease. Am J Medical Genetics: 95:432-437

15. Zamani M , Huang C, Spaepen M and Cassiman JJ and (2001): Linkage and association of the HLA class II genes with vitiligo in Dutch families. British j of Dermatology 144:90-94

16. Rahmani S.A., Mohadess S.M., Aghazadeh A, Jahani M, Izadyar M, Zamani M and Mehdipour P. (2006): Investigation of TEL/AML1 and BCR/ABL fusion genes in patients affected by acute lymphoblastic leukaemia using interphase in situ hybridization. Journal of Sciences, .I.R. of Iran 17:17-25

17. Behjati F, Atri m, Najmabadi H, Nouri K, Zamani M and Mehdipour P (2006): Prognostic value of chromosome 1 and 8 copy number in invasive Ductal breast carcinoma among Iranian women: An interphase FISH analysis. Pathology Oncology Research 11:157-163

18. Alibahksh R. and Zamani M. Mutation analysis of CFTR gene in 70 Iranian pationts by ARMS-PCR. Iranian J Allergy, Asthma and Immunology 2006 (In press)